The Arg-293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm

Mammalian circadian clocks are driven by transcription/translation feedback loops composed of positive transcriptional activators (BMAL1 and CLOCK) and negative repressors (CRYPTOCHROMEs (CRYs) and PERIODs (PERs)). CRYs, in complex with PERs, bind to the BMAL1/CLOCK complex and repress E-box–driven...

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Vydáno v:J Biol Chem
Hlavní autoři: Gul, Seref, Aydin, Cihan, Ozcan, Onur, Gurkan, Berke, Surme, Saliha, Baris, Ibrahim, Kavakli, Ibrahim Halil
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863883/
https://ncbi.nlm.nih.gov/pubmed/33028638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014333
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