Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice

There is accumulating evidence that autoimmunity to insulin B chain peptide, amino acids 9–23 (insulin B:9–23), is central to development of autoimmune diabetes of the NOD mouse model. We hypothesized that enhanced susceptibility to autoimmune diabetes is the result of targeting of insulin by a T-ce...

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Main Authors: Nakayama, Maki, Castoe, Todd, Sosinowski, Tomasz, He, XiangLing, Johnson, Kelly, Haskins, Kathryn, Vignali, Dario A.A., Gapin, Laurent, Pollock, David, Eisenbarth, George S.
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2012
Assuntos:
Immunology and Transplantation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314349/
https://ncbi.nlm.nih.gov/pubmed/22315318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1113
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