CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse

We recently established that hybrid insulin peptides (HIPs), formed in islet β-cells by fusion of insulin C-peptide fragments to peptides of chromogranin A or islet amyloid polypeptide, are ligands for diabetogenic CD4 T-cell clones. The goal of this study was to investigate whether HIP-reactive T c...

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Bibliografske podrobnosti
izdano v:Diabetes
Main Authors: Baker, Rocky L., Jamison, Braxton L., Wiles, Timothy A., Lindsay, Robin S., Barbour, Gene, Bradley, Brenda, Delong, Thomas, Friedman, Rachel S., Nakayama, Maki, Haskins, Kathryn
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2018
Teme:
Immunology and Transplantation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110316/
https://ncbi.nlm.nih.gov/pubmed/29976617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0200
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