Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes

We recently established that hybrid insulin peptides (HIPs) are present in human islets and that T cells reactive to HIPs are found in the residual islets of organ donors with type 1 diabetes (T1D). Here, we investigate whether HIP-reactive T cells are indicative of ongoing autoimmunity in patients...

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Vydáno v:Diabetes
Hlavní autoři: Baker, Rocky L., Rihanek, Marynette, Hohenstein, Anita C., Nakayama, Maki, Michels, Aaron, Gottlieb, Peter A., Haskins, Kathryn, Delong, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2019
Témata:
Immunology and Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702640/
https://ncbi.nlm.nih.gov/pubmed/31175101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0128
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