Characterization of Human CD4 T Cells Specific for a C-Peptide/C-Peptide Hybrid Insulin Peptide

Hybrid Insulin Peptides (HIPs), which consist of insulin fragments fused to other peptides from β-cell secretory granule proteins, are CD4 T cell autoantigens in type 1 diabetes (T1D). We have studied HIPs and HIP-reactive CD4 T cells extensively in the context of the non-obese diabetic (NOD) mouse...

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Udgivet i:Front Immunol
Main Authors: Wiles, Timothy A., Hohenstein, Anita, Landry, Laurie G., Dang, Mylinh, Powell, Roger, Guyer, Perrin, James, Eddie A., Nakayama, Maki, Haskins, Kathryn, Delong, Thomas, Baker, Rocky L.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185328/
https://ncbi.nlm.nih.gov/pubmed/34113344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.668680
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