Following the Fate of One Insulin-Reactive CD4 T cell: Conversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice

In diabetic patients and susceptible mice, insulin is a targeted autoantigen. Insulin B chain 9-23 (B:9-23) autoreactive CD4 T cells are key for initiating autoimmune diabetes in NOD mice; however, little is known regarding their origin and function. To this end, B:9-23–specific, BDC12-4.1 T-cell re...

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Autores principales: Fousteri, Georgia, Jasinski, Jean, Dave, Amy, Nakayama, Maki, Pagni, Philippe, Lambolez, Florence, Juntti, Therese, Sarikonda, Ghanashyam, Cheng, Yang, Croft, Michael, Cheroutre, Hilde, Eisenbarth, George, von Herrath, Matthias
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2012
Materias:
Immunology and Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331775/
https://ncbi.nlm.nih.gov/pubmed/22403296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0671
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