BDC12-4.1 T-Cell Receptor Transgenic Insulin-Specific CD4 T Cells Are Resistant to In Vitro Differentiation into Functional Foxp3(+) T Regulatory Cells

The infusion of ex vivo-expanded autologous T regulatory (Treg) cells is potentially an effective immunotherapeutic strategy against graft-versus-host disease (GvHD) and several autoimmune diseases, such as type 1 diabetes (T1D). However, in vitro differentiation of antigen-specific T cells into fun...

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Veröffentlicht in:PLoS One
Hauptverfasser: Sarikonda, Ghanashyam, Fousteri, Georgia, Sachithanantham, Sowbarnika, Miller, Jacqueline F., Dave, Amy, Juntti, Therese, Coppieters, Ken T., von Herrath, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231041/
https://ncbi.nlm.nih.gov/pubmed/25393309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112242
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