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Mechanism of substrate selection by a highly specific CRISPR endoribonuclease

Bacteria and archaea possess adaptive immune systems that rely on small RNAs for defense against invasive genetic elements. CRISPR (clustered regularly interspaced short palindromic repeats) genomic loci are transcribed as long precursor RNAs, which must be enzymatically cleaved to generate mature C...

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Autors principals: Sternberg, Samuel H., Haurwitz, Rachel E., Doudna, Jennifer A.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312554/
https://ncbi.nlm.nih.gov/pubmed/22345129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.030882.111
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