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Substrate specificity of human MCPIP1 endoribonuclease
MCPIP1, also known as Regnase-1, is a ribonuclease crucial for regulation of stability of transcripts related to inflammatory processes. Here, we report that MCPIP1 acts as an endonuclease by degrading several stem-loop RNA structures and single-stranded RNAs. Our studies revealed cleavage sites pre...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5943514/ https://ncbi.nlm.nih.gov/pubmed/29743536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25765-2 |
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