The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively

Colorectal cancers commonly carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein contributes to the stabilization of microtubules. Consistently, microtubules in cells lacking APC depolymerize more readily in response to microtubule-destabilizing drugs. This raises...

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Detalhes bibliográficos
Main Authors: Klotz, Daniel M., Nelson, Scott A., Kroboth, Karin, Newton, Ian P., Radulescu, Sorina, Ridgway, Rachel A., Sansom, Owen J., Appleton, Paul L., Näthke, Inke S.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311929/
https://ncbi.nlm.nih.gov/pubmed/22399804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.091843
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