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Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors. We provide evidence that the loss of APC leads to a partial loss of interkinetochore tension at metaphase and a...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063938/ https://ncbi.nlm.nih.gov/pubmed/17227893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200610099 |
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