The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively

Colorectal cancers commonly carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein contributes to the stabilization of microtubules. Consistently, microtubules in cells lacking APC depolymerize more readily in response to microtubule-destabilizing drugs. This raises...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Klotz, Daniel M., Nelson, Scott A., Kroboth, Karin, Newton, Ian P., Radulescu, Sorina, Ridgway, Rachel A., Sansom, Owen J., Appleton, Paul L., Näthke, Inke S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Company of Biologists 2012
विषय:
Research Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311929/
https://ncbi.nlm.nih.gov/pubmed/22399804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.091843
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