The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively

Colorectal cancers commonly carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein contributes to the stabilization of microtubules. Consistently, microtubules in cells lacking APC depolymerize more readily in response to microtubule-destabilizing drugs. This raises...

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Autori principali: Klotz, Daniel M., Nelson, Scott A., Kroboth, Karin, Newton, Ian P., Radulescu, Sorina, Ridgway, Rachel A., Sansom, Owen J., Appleton, Paul L., Näthke, Inke S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Company of Biologists 2012
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311929/
https://ncbi.nlm.nih.gov/pubmed/22399804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.091843
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