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Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7

Several classes of naturally occurring antimicrobials exert their antibiotic activity by specifically targeting aminoacyl-tRNA synthetases, validating these enzymes as drug targets. The aspartyl tRNA synthetase “Trojan horse” inhibitor microcin C7 (McC7) consists of a nonhydrolyzable aspartyl-adenyl...

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Detalhes bibliográficos
Main Authors: Agarwal, Vinayak, Tikhonov, Anton, Metlitskaya, Anastasia, Severinov, Konstantin, Nair, Satish K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311384/
https://ncbi.nlm.nih.gov/pubmed/22388748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114224109
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