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Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7
Several classes of naturally occurring antimicrobials exert their antibiotic activity by specifically targeting aminoacyl-tRNA synthetases, validating these enzymes as drug targets. The aspartyl tRNA synthetase “Trojan horse” inhibitor microcin C7 (McC7) consists of a nonhydrolyzable aspartyl-adenyl...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3311384/ https://ncbi.nlm.nih.gov/pubmed/22388748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114224109 |
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