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Saposins utilize two strategies for lipid transfer and CD1 antigen presentation

Transferring lipid antigens from membranes into CD1 antigen-presenting proteins represents a major molecular hurdle necessary for T-cell recognition. Saposins facilitate this process, but the mechanisms used are not well understood. We found that saposin B forms soluble saposin protein–lipid complex...

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Main Authors: León, Luis, Tatituri, Raju V. V., Grenha, Rosa, Sun, Ying, Barral, Duarte C., Minnaard, Adriaan J., Bhowruth, Veemal, Veerapen, Natacha, Besra, Gurdyal S., Kasmar, Anne, Peng, Wei, Moody, D. Branch, Grabowski, Gregory A., Brenner, Michael B.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2012
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311357/
https://ncbi.nlm.nih.gov/pubmed/22331868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200764109
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