Saposins utilize two strategies for lipid transfer and CD1 antigen presentation

Transferring lipid antigens from membranes into CD1 antigen-presenting proteins represents a major molecular hurdle necessary for T-cell recognition. Saposins facilitate this process, but the mechanisms used are not well understood. We found that saposin B forms soluble saposin protein–lipid complex...

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Main Authors: León, Luis, Tatituri, Raju V. V., Grenha, Rosa, Sun, Ying, Barral, Duarte C., Minnaard, Adriaan J., Bhowruth, Veemal, Veerapen, Natacha, Besra, Gurdyal S., Kasmar, Anne, Peng, Wei, Moody, D. Branch, Grabowski, Gregory A., Brenner, Michael B.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311357/
https://ncbi.nlm.nih.gov/pubmed/22331868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200764109
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