Saposins utilize two strategies for lipid transfer and CD1 antigen presentation

Transferring lipid antigens from membranes into CD1 antigen-presenting proteins represents a major molecular hurdle necessary for T-cell recognition. Saposins facilitate this process, but the mechanisms used are not well understood. We found that saposin B forms soluble saposin protein–lipid complex...

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Detalhes bibliográficos
Main Authors: León, Luis, Tatituri, Raju V. V., Grenha, Rosa, Sun, Ying, Barral, Duarte C., Minnaard, Adriaan J., Bhowruth, Veemal, Veerapen, Natacha, Besra, Gurdyal S., Kasmar, Anne, Peng, Wei, Moody, D. Branch, Grabowski, Gregory A., Brenner, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311357/
https://ncbi.nlm.nih.gov/pubmed/22331868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200764109
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