Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection

Invariant natural killer T cells (iNKT cells) are critical for host defense against a variety of microbial pathogens. However, the central question of how iNKT cells are activated by microbes has not been fully explained. The example of adaptive MHC-restricted T cells, studies using synthetic pharma...

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Detalhes bibliográficos
Main Authors: Brigl, Manfred, Tatituri, Raju V.V., Watts, Gerald F.M., Bhowruth, Veemal, Leadbetter, Elizabeth A., Barton, Nathaniel, Cohen, Nadia R., Hsu, Fong-Fu, Besra, Gurdyal S., Brenner, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173255/
https://ncbi.nlm.nih.gov/pubmed/21555485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20102555
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