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GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry

Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(−)Sca1(+)c-Kit(hi)CD150(+)CD48(−)) are quiescent, with only a small percentage of the...

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Autors principals: Ku, Chia-Jui, Hosoya, Tomonori, Maillard, Ivan, Engel, James Douglas
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311255/
https://ncbi.nlm.nih.gov/pubmed/22267605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-366070
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