Activation of Protein Kinase C (PKC)α or PKCε as an Approach to Increase Morphine Tolerance in Respiratory Depression and Lethal Overdose

Long-term use of opioids is hindered by respiratory depression and the possibility for fatal overdose in drug abusers. This is attributed to higher levels of tolerance that develops against antinociception than to respiratory depression. Identifying important mechanisms that would increase morphine...

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Bibliografiska uppgifter
Huvudupphovsmän: Lin, Hong-Yiou, Law, Ping-Yee, Loh, Horace H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2012
Ämnen:
Neuropharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310699/
https://ncbi.nlm.nih.gov/pubmed/22228806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.188235
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