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Spinal or supraspinal phosphorylation deficiency at the MOR C- terminus does not affect morphine tolerance in vivo

The development of tolerance to morphine, one of the most potent analgesics, in the management of chronic pain is a significant clinical problem and its mechanisms are poorly understood. Morphine exerts its pharmacological effects via the μ-opioid receptor (MOR). Tolerance is highly connected to G-p...

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Bibliografiske detaljer
Udgivet i:Pharmacol Res
Main Authors: Kibaly, Cherkaouia, Lin, Hong-Yiou, Loh, Horace H, Law, Ping-Yee
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392433/
https://ncbi.nlm.nih.gov/pubmed/28179123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2017.01.033
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