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Spinal or supraspinal phosphorylation deficiency at the MOR C- terminus does not affect morphine tolerance in vivo
The development of tolerance to morphine, one of the most potent analgesics, in the management of chronic pain is a significant clinical problem and its mechanisms are poorly understood. Morphine exerts its pharmacological effects via the μ-opioid receptor (MOR). Tolerance is highly connected to G-p...
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| Опубликовано в: : | Pharmacol Res |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5392433/ https://ncbi.nlm.nih.gov/pubmed/28179123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2017.01.033 |
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