Modulating μ-Opioid Receptor Phosphorylation Switches Agonist-dependent Signaling as Reflected in PKCϵ Activation and Dendritic Spine Stability

A new role of G protein-coupled receptor (GPCR) phosphorylation was demonstrated in the current studies by using the μ-opioid receptor (OPRM1) as a model. Morphine induces a low level of receptor phosphorylation and uses the PKCϵ pathway to induce ERK phosphorylation and receptor desensitization, wh...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Zheng, Hui, Chu, Ji, Zhang, Yuhan, Loh, Horace H., Law, Ping-Yee
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069472/
https://ncbi.nlm.nih.gov/pubmed/21292762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177089
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares