Modulating μ-Opioid Receptor Phosphorylation Switches Agonist-dependent Signaling as Reflected in PKCϵ Activation and Dendritic Spine Stability

A new role of G protein-coupled receptor (GPCR) phosphorylation was demonstrated in the current studies by using the μ-opioid receptor (OPRM1) as a model. Morphine induces a low level of receptor phosphorylation and uses the PKCϵ pathway to induce ERK phosphorylation and receptor desensitization, wh...

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Detaylı Bibliyografya
Asıl Yazarlar: Zheng, Hui, Chu, Ji, Zhang, Yuhan, Loh, Horace H., Law, Ping-Yee
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069472/
https://ncbi.nlm.nih.gov/pubmed/21292762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177089
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