Activation of Protein Kinase C (PKC)α or PKCε as an Approach to Increase Morphine Tolerance in Respiratory Depression and Lethal Overdose

Long-term use of opioids is hindered by respiratory depression and the possibility for fatal overdose in drug abusers. This is attributed to higher levels of tolerance that develops against antinociception than to respiratory depression. Identifying important mechanisms that would increase morphine...

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Detaylı Bibliyografya
Asıl Yazarlar: Lin, Hong-Yiou, Law, Ping-Yee, Loh, Horace H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2012
Konular:
Neuropharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310699/
https://ncbi.nlm.nih.gov/pubmed/22228806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.188235
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