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Activation of Protein Kinase C (PKC)α or PKCε as an Approach to Increase Morphine Tolerance in Respiratory Depression and Lethal Overdose

Long-term use of opioids is hindered by respiratory depression and the possibility for fatal overdose in drug abusers. This is attributed to higher levels of tolerance that develops against antinociception than to respiratory depression. Identifying important mechanisms that would increase morphine...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lin, Hong-Yiou, Law, Ping-Yee, Loh, Horace H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310699/
https://ncbi.nlm.nih.gov/pubmed/22228806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.188235
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