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Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family
N(ϵ)-Methylations of histone lysine residues play critical roles in cell biology by “marking” chromatin for transcriptional activation or repression. Lysine demethylases reverse N(ϵ)-methylation in a sequence- and methylation-selective manner. The determinants of sequence selectivity for histone dem...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3308871/ https://ncbi.nlm.nih.gov/pubmed/21914792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.283689 |
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