Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

N(ϵ)-Methylations of histone lysine residues play critical roles in cell biology by “marking” chromatin for transcriptional activation or repression. Lysine demethylases reverse N(ϵ)-methylation in a sequence- and methylation-selective manner. The determinants of sequence selectivity for histone dem...

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Main Authors: Hillringhaus, Lars, Yue, Wyatt W., Rose, Nathan R., Ng, Stanley S., Gileadi, Carina, Loenarz, Christoph, Bello, Simon H., Bray, James E., Schofield, Christopher J., Oppermann, Udo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
DNA and Chromosomes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308871/
https://ncbi.nlm.nih.gov/pubmed/21914792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.283689
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