Cytosolic Bax: DOES IT REQUIRE BINDING PROTEINS TO KEEP ITS PRO-APOPTOTIC ACTIVITY IN CHECK?

Bax is kept inactive in the cytosol by refolding its C-terminal transmembrane domain into the hydrophobic binding pocket. Although energetic calculations predicted this conformation to be stable, numerous Bax binding proteins were reported and suggested to further stabilize inactive Bax. Unfortunate...

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Autors principals: Vogel, Sandra, Raulf, Nina, Bregenhorn, Stephanie, Biniossek, Martin L., Maurer, Ulrich, Czabotar, Peter, Borner, Christoph
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308772/
https://ncbi.nlm.nih.gov/pubmed/22277657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.248906
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