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Conformational control of Bax localization and apoptotic activity by Pro168
In healthy cells, Bax resides inactive in the cytosol because its COOH-terminal transmembrane region (TMB) is tucked into a hydrophobic pocket. During apoptosis, Bax undergoes a conformational change involving NH(2)-terminal exposure and translocates to mitochondria to release apoptogenic factors. H...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172067/ https://ncbi.nlm.nih.gov/pubmed/15037603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200309013 |
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