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Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
Human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC), a key oxidation product of 5-methylcytosine in a recently discovered cytosine demethylation pathway. We present here the crystal structures of hTDG catalytic domain in complex with duplex DNA containing either 5caC o...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307914/ https://ncbi.nlm.nih.gov/pubmed/22327402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.914 |
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