Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

Human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC), a key oxidation product of 5-methylcytosine in a recently discovered cytosine demethylation pathway. We present here the crystal structures of hTDG catalytic domain in complex with duplex DNA containing either 5caC o...

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Detalhes bibliográficos
Main Authors: Zhang, Liang, Lu, Xingyu, Lu, Junyan, Liang, Haihua, Dai, Qing, Xu, Guo-Liang, Luo, Cheng, Jiang, Hualiang, He, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307914/
https://ncbi.nlm.nih.gov/pubmed/22327402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.914
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