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Synthesis of DNA oligos containing 2′-deoxy-2′-fluoro-D-arabinofuranosyl-5-carboxylcytosine as hTDG inhibitor

As an important step of the active demethylation of 5-methylcytosine (5mC), human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC) from double-stranded DNA (dsDNA). Here, we present synthesis of DNA oligos containing a 2′-deoxy-2′-fluoro-D-arabinofuranosyl-5-carboxylcytid...

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Bibliografske podrobnosti
Main Authors: Dai, Qing, Lu, Xingyu, Zhang, Liang, He, Chuan
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375917/
https://ncbi.nlm.nih.gov/pubmed/22711938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2012.04.031
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