Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demethylation via the base excision repair pathway. TDG excises the mismatched base from G:X mismatches, where X is uracil, thymine or 5-hydroxymethyluracil (5hmU). These are, respectively, the deamination products of cytosine,...

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Bibliographic Details
Main Authors: Hashimoto, Hideharu, Hong, Samuel, Bhagwat, Ashok S., Zhang, Xing, Cheng, Xiaodong
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488261/
https://ncbi.nlm.nih.gov/pubmed/22962365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks845
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