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Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH

The mammalian thymine DNA glycosylase (TDG) excises 5-carboxylcytosine (5caC) when paired with a guanine in a CpG sequence, in addition to mismatched bases. Here we present a complex structure of the human TDG catalytic mutant, asparagine 140 to alanine (N140A), with a 28-base pair DNA containing a...

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Detalhes bibliográficos
Main Authors: Hashimoto, Hideharu, Zhang, Xing, Cheng, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758246/
https://ncbi.nlm.nih.gov/pubmed/23680598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.04.003
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