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Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demethylation via the base excision repair pathway. TDG excises the mismatched base from G:X mismatches, where X is uracil, thymine or 5-hydroxymethyluracil (5hmU). These are, respectively, the deamination products of cytosine,...

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Bibliografiske detaljer
Main Authors: Hashimoto, Hideharu, Hong, Samuel, Bhagwat, Ashok S., Zhang, Xing, Cheng, Xiaodong
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488261/
https://ncbi.nlm.nih.gov/pubmed/22962365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks845
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