Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts

Treatment of base excision repair-proficient mouse fibroblasts with the DNA alkylating agent methyl methanesulfonate (MMS) and a small molecule inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) results in a striking cell killing phenotype, as previously reported. Earlier studies demonstrated that...

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Bibliographic Details
Main Authors: Kedar, Padmini S., Stefanick, Donna F., Horton, Julie K., Wilson, Samuel H.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307909/
https://ncbi.nlm.nih.gov/pubmed/22246237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0477
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