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Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts
Treatment of base excision repair-proficient mouse fibroblasts with the DNA alkylating agent methyl methanesulfonate (MMS) and a small molecule inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) results in a striking cell killing phenotype, as previously reported. Earlier studies demonstrated that...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307909/ https://ncbi.nlm.nih.gov/pubmed/22246237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0477 |
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