Dimeric α-Cobratoxin X-ray Structure: LOCALIZATION OF INTERMOLECULAR DISULFIDES AND POSSIBLE MODE OF BINDING TO NICOTINIC ACETYLCHOLINE RECEPTORS

In Naja kaouthia cobra venom, we have earlier discovered a covalent dimeric form of α-cobratoxin (αCT-αCT) with two intermolecular disulfides, but we could not determine their positions. Here, we report the αCT-αCT crystal structure at 1.94 Å where intermolecular disulfides are identified between Cy...

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Detalhes bibliográficos
Main Authors: Osipov, Alexey V., Rucktooa, Prakash, Kasheverov, Igor E., Filkin, Sergey Yu., Starkov, Vladislav G., Andreeva, Tatyana V., Sixma, Titia K., Bertrand, Daniel, Utkin, Yuri N., Tsetlin, Victor I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307301/
https://ncbi.nlm.nih.gov/pubmed/22223648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322313
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