Distamycin inhibition of topoisomerase I-DNA interaction: a mechanistic analysis.

Inhibition of eukaryotic DNA topoisomerase I by the minor groove binding ligand, distamycin A, was investigated. Low concentrations of the ligand selectively prevented catalytic action at a high affinity topoisomerase I binding sequence. A restriction enzyme protection assay indicated that the catal...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Mortensen, U H, Stevnsner, T, Krogh, S, Olesen, K, Westergaard, O, Bonven, B J
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 1990
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330672/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2159632/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/18.8.1983
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars