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Distamycin inhibition of topoisomerase I-DNA interaction: a mechanistic analysis.

Inhibition of eukaryotic DNA topoisomerase I by the minor groove binding ligand, distamycin A, was investigated. Low concentrations of the ligand selectively prevented catalytic action at a high affinity topoisomerase I binding sequence. A restriction enzyme protection assay indicated that the catal...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Mortensen, U H, Stevnsner, T, Krogh, S, Olesen, K, Westergaard, O, Bonven, B J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 1990
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330672/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2159632/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/18.8.1983
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