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Distamycin inhibition of topoisomerase I-DNA interaction: a mechanistic analysis.
Inhibition of eukaryotic DNA topoisomerase I by the minor groove binding ligand, distamycin A, was investigated. Low concentrations of the ligand selectively prevented catalytic action at a high affinity topoisomerase I binding sequence. A restriction enzyme protection assay indicated that the catal...
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| Publié dans: | Nucleic Acids Res |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
1990
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| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330672/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2159632/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/18.8.1983 |
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