Distamycin inhibition of topoisomerase I-DNA interaction: a mechanistic analysis.

Inhibition of eukaryotic DNA topoisomerase I by the minor groove binding ligand, distamycin A, was investigated. Low concentrations of the ligand selectively prevented catalytic action at a high affinity topoisomerase I binding sequence. A restriction enzyme protection assay indicated that the catal...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Mortensen, U H, Stevnsner, T, Krogh, S, Olesen, K, Westergaard, O, Bonven, B J
Médium: Artigo
Jazyk:Inglês
Vydáno: 1990
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC330672/
https://ncbi.nlm.nih.gov/pubmed/2159632
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky