Distamycin inhibition of topoisomerase I-DNA interaction: a mechanistic analysis.

Inhibition of eukaryotic DNA topoisomerase I by the minor groove binding ligand, distamycin A, was investigated. Low concentrations of the ligand selectively prevented catalytic action at a high affinity topoisomerase I binding sequence. A restriction enzyme protection assay indicated that the catal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mortensen, U H, Stevnsner, T, Krogh, S, Olesen, K, Westergaard, O, Bonven, B J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1990
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC330672/
https://ncbi.nlm.nih.gov/pubmed/2159632
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak