Distamycin inhibition of topoisomerase I-DNA interaction: a mechanistic analysis.

Inhibition of eukaryotic DNA topoisomerase I by the minor groove binding ligand, distamycin A, was investigated. Low concentrations of the ligand selectively prevented catalytic action at a high affinity topoisomerase I binding sequence. A restriction enzyme protection assay indicated that the catal...

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Bibliografiset tiedot
Päätekijät: Mortensen, U H, Stevnsner, T, Krogh, S, Olesen, K, Westergaard, O, Bonven, B J
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1990
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC330672/
https://ncbi.nlm.nih.gov/pubmed/2159632
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