The Complete Reaction Mechanism of Indoleamine 2,3-Dioxygenase as Revealed by QM/MM Simulations

Indoleamine 2,3 dioxygenase (IDO) and tryptophan dioxygenase (TDO) are two heme-proteins that catalyze the oxidation reaction of tryptophan (Trp) to N-formylkynurenine (NFK). Human IDO (hIDO) has recently been recognized as a potent anti-cancer drug target, a fact that triggered intense research on...

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Detaylı Bibliyografya
Asıl Yazarlar: Capece, Luciana, Lewis-Ballester, Ariel, Yeh, Syun-Ru, Estrin, Dario A., Marti, Marcelo A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304497/
https://ncbi.nlm.nih.gov/pubmed/22196056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp2082825
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