טוען...
The Complete Reaction Mechanism of Indoleamine 2,3-Dioxygenase as Revealed by QM/MM Simulations
Indoleamine 2,3 dioxygenase (IDO) and tryptophan dioxygenase (TDO) are two heme-proteins that catalyze the oxidation reaction of tryptophan (Trp) to N-formylkynurenine (NFK). Human IDO (hIDO) has recently been recognized as a potent anti-cancer drug target, a fact that triggered intense research on...
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| Main Authors: | , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3304497/ https://ncbi.nlm.nih.gov/pubmed/22196056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp2082825 |
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