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Targeting HIV-1 Envelope Glycoprotein Trimers to B Cells by Using APRIL Improves Antibody Responses

An HIV-1 vaccine remains elusive, in part because various factors limit the quantity and quality of the antibodies raised against the viral envelope glycoprotein complex (Env). We hypothesized that targeting Env vaccines directly to B cells, by fusing them to molecules that bind and activate these c...

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Main Authors: Melchers, Mark, Bontjer, Ilja, Tong, Tommy, Chung, Nancy P. Y., Klasse, Per Johan, Eggink, Dirk, Montefiori, David C., Gentile, Maurizio, Cerutti, Andrea, Olson, William C., Berkhout, Ben, Binley, James M., Moore, John P., Sanders, Rogier W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302291/
https://ncbi.nlm.nih.gov/pubmed/22205734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06259-11
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