A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells

BACKGROUND: One reason why subunit protein and DNA vaccines are often less immunogenic than live-attenuated and whole-inactivated virus vaccines is that they lack the co-stimulatory signals provided by various components of the more complex vaccines. The HIV-1 envelope glycoprotein complex (Env) is...

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Autori principali: Melchers, Mark, Matthews, Katie, de Vries, Robert P, Eggink, Dirk, van Montfort, Thijs, Bontjer, Ilja, van de Sandt, Carolien, David, Kathryn, Berkhout, Ben, Moore, John P, Sanders, Rogier W
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141652/
https://ncbi.nlm.nih.gov/pubmed/21689404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-48
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