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Stabilized HIV-1 Envelope Glycoprotein Trimers Lacking the V1V2 Domain, Obtained by Virus Evolution

The envelope glycoproteins (Env) are the focus of HIV-1 vaccine development strategies based on the induction of humoral immunity, but the mechanisms the virus has evolved to limit the induction and binding of neutralizing antibodies (NAbs) constitute substantial obstacles. Conserved neutralization...

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Detalhes bibliográficos
Main Authors: Bontjer, Ilja, Melchers, Mark, Eggink, Dirk, David, Kathryn, Moore, John P., Berkhout, Ben, Sanders, Rogier W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978575/
https://ncbi.nlm.nih.gov/pubmed/20826824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156588
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