Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.

The mechanism of action of macrophage colony-stimulating factor (M-CSF) in osteoclast development was examined in a co-culture system of mouse osteoblastic cells and spleen cells. In this co-culture, osteoclast-like multinucleated cells (MNCs) were formed within 6 d in response to 10 nM 1 alpha,25(O...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Tanaka, S, Takahashi, N, Udagawa, N, Tamura, T, Akatsu, T, Stanley, E R, Kurokawa, T, Suda, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1993
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Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330022/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8423223/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116179
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