Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.

IL-18 inhibits osteoclast (OCL) formation in vitro independent of IFN-gamma production, and this was abolished by the addition of neutralizing antibodies to GM-CSF. We now establish that IL-18 was unable to inhibit OCL formation in cocultures using GM-CSF-deficient mice (GM-CSF -/-). Reciprocal cocu...

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Detalhes bibliográficos
Main Authors: Horwood, N J, Udagawa, N, Elliott, J, Grail, D, Okamura, H, Kurimoto, M, Dunn, A R, Martin, T, Gillespie, M T
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC508603/
https://ncbi.nlm.nih.gov/pubmed/9449693
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