Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.

The mechanism of action of macrophage colony-stimulating factor (M-CSF) in osteoclast development was examined in a co-culture system of mouse osteoblastic cells and spleen cells. In this co-culture, osteoclast-like multinucleated cells (MNCs) were formed within 6 d in response to 10 nM 1 alpha,25(O...

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Detalhes bibliográficos
Main Authors: Tanaka, S, Takahashi, N, Udagawa, N, Tamura, T, Akatsu, T, Stanley, E R, Kurokawa, T, Suda, T
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC330022/
https://ncbi.nlm.nih.gov/pubmed/8423223
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